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Image Search Results
Journal: Pharmaceutics
Article Title: Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation
doi: 10.3390/pharmaceutics10030112
Figure Lengend Snippet: Chemical structure of loxoprofen and its metabolites ( a ). Metabolic stability of 5 µM of loxoprofen in 0.25 mg/mL of human liver cytosols (HLC) in the presence of β-reduced nicotinamide adenine dinucleotide phosphate (β-NADPH) regeneration system (NGS) and 0.25 mg/mL of human liver microsomes (HLMs) in the presence of NGS and uridine 5′-diphosphoglucuronic acid trisodium (UDPGA) incubated at 37 °C for 60 min ( b ). The data are represented as mean ± standard error (S.E) of the triplicate samples.
Article Snippet: The β-reduced
Techniques: Incubation
Journal: Pharmaceutics
Article Title: Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation
doi: 10.3390/pharmaceutics10030112
Figure Lengend Snippet: The extracted ion chromatograph (EIC); DEX, dexamethasone EIC of loxoprofen and its metabolites in human liver cytosols (HLC) ( a ) and human liver microsomes (HLM) ( b ) in presence of β-NADPH regeneration system (NGS), HLMs in presence of NGS and UDPGA ( c ), and dexamethasone (DEX)-induced rat liver microsomes ( d ) in the presence of NGS.
Article Snippet: The β-reduced
Techniques: